Types of Breast Cancer
What are the most common types of breast cancer? Breast Cancer Is the second leading cause of cancer death in women, approximately 40,000 deaths per year. When looking at breast cancer statistics, you will notice a big difference between diagnosed cases and deaths (the scale tips toward survival rate). The only reason is the screening programs and early diagnostic. Again, 80% of primary breast cancers are called infiltrating ductal cancers. They are adenocarcinomas’. There are also subtypes like lobular and nipple cancers. But again, the vast majority are adenocarcinomas.
Most of the types of breast cancer are adenocarcinomas. They account for 80% of the total occurrences of breast cancer and they are also called infiltrating ductal cancers and they grow outward. Others are lobular (in the lobules of the gland) and nipple breast cancer. They manifest themselves as a large growing mass. Breast cancer is the most common in women and the second leading cause of death among the types of Cancer. The genes responsible for the DNA repair are breast cancer one gene or BRCA1 and breast cancer two or BRCA2. Mutations of those genes increase the risk with 55 %to 65% and 45% accordingly.
What is the Structure of Breast Cancer Cells? Types of Breast Cancer
The type of breast cancer cells is very important for the treatment. The outside wall of breast cancer cells contains receptors. These receptors can catch specific female hormones that circulate in the body estrogen and progesterone. When the specific hormone is defined, the health care professional has a better idea of the best-needed treatment and prevention of breast cancer recurring.
What are the Hormones that may be Included in the Types of Breast Cancer?
The most important thing to know is what kind of receptors have breast cancer cells. This knowledge defines the treatment, and the physicians know the kind of hormones he or she has to deal with. Breast hormones status is defined as follows:
- Breast cancer cells that have Estrogen positive receptors.The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone therapy blocks the growth of the cancer cells.
- Breast cancer cells that have Progesterone positive receptors.This type of breast cancer is sensitive to progesterone, and the cells have receptors that allow them to use this hormone to grow. Treatment with anti-progesterone hormone therapy can block the growth of the cancer cells.
- Breast cancer cells that have Hormone negative receptors.This type of cancer doesn’t have hormone receptors, so it won’t be affected by hormone treatments whose goal is to block hormones in the body.
According to the statistic, breast cancer occurs in 1 out of 8 women under the age of 45 and 2/3 of the cancer occurrence are in women over the age of 50. Family history is an important factor in this type of cancer. Having relatives, first line, with a history of cancer doubles the risk of this cancer. Science proved the presence of mutated genes associated with it and their relation to an increased risk of occurrence. A gene known as BRCA1 (breast cancer 1 – Chromosome 17) is a tumor suppressor and acts as a repair pathway in the DNA. Its role is to restrain or stop the growth of cells in the breast.
When Mutation exists in BRCA1, it increases the risk of breast cancer occurrence by 55-65%. The later is more often linked to the development of triple-negative breast cancer. This type of cancer is the hardest to cure among all forms of breast cancer. The second genes are BRCA2 (chromosome 13) increases the risk of breast cancer by 45%. You have to keep in mind that not all women who have those mutated genes are affected by cancer, yet, they are at higher risk. It is important to know that breast cancer does not affect all women with genes mutation and not all women affected have a hereditary history – According to scientists 10-15% of women who have genes mutation, BRCA1 or BRCA2 may have breast cancer in a lifetime. Other contributing factors to breast cancer are oral contraceptive use, postmenopausal hormone therapy.